Senior Research Scientist – Structure Guided Protein Engineering

Evolve Scientific is proudly partnering with AbCellera in the recruitment of a Senior Research Scientist – Structure Guided Protein Engineering.

A clinical-stage biotechnology company focused on discovering and developing antibody-based medicines in the areas of endocrinology, women’s health, immunology, and oncology. They have built a platform for advancing antibody drug programs from target to clinic, and using it to build their internal pipeline.
 
Seeking an exceptional computational scientist to drive structure-guided protein engineering and affinity maturation, with an emphasis on monoclonal antibody therapeutics and complex antibody-protein interactions. Your role sits at the intersection of high resolution structural data and in-silico therapeutic design, partnering closely with wet-lab teams to deliver engineered molecules with measurable improvements in affinity, specificity, and developability. If you are a scientist that engages in critical thinking and applies problem-solving skills to enable the successful transition of a pre-clinical candidate to clinical asset, we’d love to hear from you. 
 
How you might spend your days: 

• Designing, implementing, and evaluating in-silico protein engineering activities to support optimisation and maturation of antibody-based therapeutic assets
• Refining computational models based on real-world wet-lab data to bridge the gap between in-silico predictions and physical antibody therapeutic performance
• Collaborating with teams across the company to understand engineering challenges and propose solutions
• Preparing and authoring materials to educate colleagues and communicate strategies, key findings, and implications

 
We’d love to hear from you if: 

• You have a PhD in Biochemistry, Computational Biology, or a related field, experience in a biological research setting
• You are a collaborative team player that can contribute to the design, execution, and evaluation of in-silico protein engineering workflows
• You are strongly self-motivated and work independently to identify project needs and follow that up with building and implementing solutions
• You demonstrate deep expertise in scientific programming, with advanced proficiency in Python applied to protein engineering workflows 
• You possess deep domain expertise of antibody structure and function, and familiarity with techniques applicable to the molecular design, engineering, and experimental evaluation of antibody and/or antigen libraries for protein engineering purposes 
• You have in-depth experience with machine-learning, AI, and/or physics-based techniques used to perform in-silico protein design
• You have a deep understanding of therapeutic antibody development and structural biology (this is desirable, but not required)  

What we offer: 

• Easy transport access
• The opportunity to work with an inspired team on challenging problems that matter
• An attractive compensation package, including a competitive salary and health, bonus and lifestyle benefits
• Opportunity to lead cutting-edge antibody development programs.
• Collaborative environment with global exposure.
• Extended summer closure, as well as professional development opportunities. Scientific and technical mentorship is a priority. 

How to Apply:

If you think this could be the role for you then please apply now via the link, including a cover letter AND a detailed resume.
 
Do not contact AbCellera directly. If you have any questions, please contact Susan on susan.macleod@evolvescientific.com.au

With over 90 years' combined experience, NES Fircroft (NES) is proud to be the world's leading engineering staffing provider spanning the Oil & Gas, Power & Renewables, Chemicals, Construction & Infrastructure, Life Sciences, Mining and Manufacturing sectors worldwide. With more than 80 offices in 45 countries, we are able to provide our clients with the engineering and technical expertise they need, wherever and whenever it is needed. We offer contractors far more than a traditional recruitment service, supporting with everything from securing visas and work permits, to providing market-leading benefits packages and accommodation, ensuring they are safely and compliantly able to support our clients.